The Public Accounts Committee said setting targets in England for the two infections had led to a fall in cases.
But they warned there were signs other bugs, such as E. coli, were becoming more common and they called for better surveillance to curb the problem.
The Department of Health said it was already looking into the issue.
In England, MRSA rates are now a quarter of what they were at their peak in 2004, while C. difficile rates have fallen by nearly a third in the past year, following the introduction of targets.
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